Dupuytrens disease is a benign proliferative connective tissue disorder that involves the hands palmar fascia. Inherited in an autosomal dominant pattern, the disease is characterized by a nodular thickening of the palmar fascia metacarpophalangeal and proximal interphalangeal joints. Dupuytrens contracture is a condition in which one or more fingers become permanently bent in a flexed position. An investigation conducted on behalf of the british government among lace minders showed an incidence of. This disorder causes functional limitations, but it can be treated through a. It was observed a higher incidence of dupuytrens disease was observed among men, chakkour i. It is characterized by the presence of spindleshaped fibroblasts, and an infiltrative growth pattern. Mapping of an autosomal dominant gene for dupuytrens contracture to chromosome 16q in a swedish family. It usually begins as small, hard nodules just under the skin of the palm, then worsens over time until the fingers can no longer be straightened.
Mapping of an autosomal dominant gene for dupuytrens contracture to chromosome 16q in a. Dupuytren, himself, 24 considered repetitive trauma of the handpalm to be the cause of the contracture. Palm aponeurosis, also known as dupuytrens disease, was initially described by felix platter in. After removal of the wires, the joint is fixed into flexion, which is considered preferable to fusion at extension. Dupuytrens disease is a benign fibroproliferative disorder that causes the fingers to be drawn into the palm via formation of new tissue under the glabrous skin of the hand.
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